Among the various activities which take place at Grandpont House, those of a spiritual or doctrinal nature are entrusted to Opus Dei, a personal prelature of the Catholic Church []. The founder of Opus Dei, St Josemaría Escrivá, visited Oxford and the site of Grandpont House in 1958 [].

The members of Opus Dei are ordinary men and women who strive to live out the demands of the Christian life wherever they find themselves, in the middle of the world and amidst the ordinary occupations of life. The spiritual activities offered at Grandpont are geared to enabling the lay person to do just this: to practice the Christian virtues in everyday work and other ordinary social and family settings. 

Series of talks and one-day conferences are held explaining aspects of Christian doctrine and its application to student, professional and family life, and the resident Opus Dei priest is available for individual spiritual guidance. There are also opportunities to attend each year silent retreats [] and [].